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June 9, 2026Neurology

Once-nightly Sodium Oxybate Improves Symptoms in People With Narcolepsy: Interim Results From the Real-world REFRESH Study (P6-14.007)

Sarah Meskill Gerard Meskill Asim Roy Adrian Santamaria Robyn Porpiglio Oktai Mamedov Sally Ibrahim Omavi Bailey Richard Bogan Laura B. Herpel J. P. McConnell Gretchen S. Richards Brian Abaluck Jennifer Gudeman

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Key Points

The aim is to report interim findings on the effectiveness of once-nightly sodium oxybate for narcolepsy symptoms.
Real-world study design assessing the effects of once-nightly sodium oxybate
Patient population included individuals diagnosed with narcolepsy
Interim results analysis from registry NCT06792708.
Patients reported significant improvement in narcolepsy symptoms with once-nightly sodium oxybate
Effectiveness was observed in reducing daytime sleepiness and improving overall alertness.

Implication

Shows improved symptoms in narcolepsy, suggesting effective treatment with sodium oxybate.

Abstract

To report interim results from REFRESH (NCT06792708), a real-world study of once-nightly sodium oxybate (ON-SXB) for narcolepsy.

Discussion

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Cite This Study

Meskill et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3d6faef96ed7f0563a0 https://doi.org/10.1212/wnl.0000000000215382

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

10752 Once-Nightly Sodium Oxybate Improves Symptoms in People with Narcolepsy: Final Results from the Real-World REFRESH StudyOriginal Research · 2026
20766 Real-World Experience of Once-Nightly Sodium Oxybate Treatment in People with Narcolepsy: Final Results from REFRESHOriginal Research · 2026
3Consistent Efficacy of Once-nightly Sodium Oxybate Regardless of Patient Demographic and Baseline Disease Characteristics (P10-9.008)2024
4Efficacy of Once-Nightly Sodium Oxybate (FT218) on Daytime Symptoms in Individuals With Narcolepsy With or Without Concomitant Alerting Agent Use: A Post Hoc Analysis From the Phase 3 REST-ON Trial2024 · 3 citations
5Long-term Safety and Efficacy of Extended-release Once-nightly Sodium Oxybate for Narcolepsy in Patients not Currently Taking an Oxybate (P6-14.004)Original Research · 2026

Once‐Nightly Sodium Oxybate Meets American Academy of Sleep Medicine Criteria for Treatment of Narcolepsy2025
0643 Patient Preferences of Sodium Oxybate Treatment for Narcolepsy: RESTORE End-of-Study Survey Data2024
Weight Loss With Once-nightly Sodium Oxybate for the Treatment of Narcolepsy: Analysis From the Phase III Randomized study Evaluating the efficacy and SafeTy of a ONce nightly formulation of sodium oxybate (REST-ON) Trial2024
Differences in Epilepsy Etiology, Type, Syndrome, and Severity Between Māori and Non-Māori-Non-Pasifika Children With Epilepsy in New ZealandNeurology · 2026
Teaching NeuroImage: Opioid-Associated Amnestic SyndromeNeurology · 2026

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