Examines the effectiveness of various sterilization methods on bacterial endotoxin, suggesting alternatives for manufacturers.
The current work demonstrated inactivation of bacterial endotoxin by moist heat, electron beam, and gamma irradiation in dry, water, and saline conditions relevant to medical devices and pharmaceuticals. This study was intended to help manufacturers decide whether to test for bacterial endotoxin pre- or poststerilization. It demonstrated the feasibility of inactivating endotoxin by widely available sterilization technologies other than dry heat.
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Brydon et al. (2026) studied this question.
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