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June 9, 2026Neurology

When to Question Cerebral Palsy: Hereditary Spastic Paraplegia Masquerading as Cerebral Palsy (P4-8.006)

Swathi Nagabushan Avi Landman

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Key Points

This report aims to highlight the diagnostic challenges in differentiating between cerebral palsy and hereditary spastic paraplegia.
Case report detailing patient history and symptoms of lower-extremity weakness.
Genetic testing performed to confirm diagnosis after initial assessment suggested cerebral palsy.
Initial diagnosis of cerebral palsy was made based on symptoms.
Further genetic testing revealed the condition to be hereditary spastic paraplegia, altering the treatment approach.

Implication

Case report reclassifies lower-extremity weakness from cerebral palsy to hereditary spastic paraplegia, indicating diagnostic complexities.

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Cite This Study

Nagabushan et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3d6faef96ed7f056441 https://doi.org/10.1212/wnl.0000000000216632

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Early-onset Hereditary Spastic Paraplegia (SPG3A) Misdiagnosed as Diplegic Cerebral Palsy in a Child With Multigenerational Family History and Normal Birth (P3-9.005)Original Research · 2026
2Hereditary Spastic Paraparesis Mimicking Primary Progressive Multiple Sclerosis Due to CYP7B1 Gene Mutation: A Case Report2024
3Hereditary spastic paraplegia: a practical approachOriginal Research · 2026
4<scp> <i>SPG4</i> </scp> Hereditary Spastic Paraplegia: From Etiology to TherapyOriginal Research · 2026
5Pure hereditary spastic paraplegia.Original Research · 1997 · 82 citations

More related papers

A – 51 The Clinical Utility of Longitudinal Neuropsychological Evaluation in Pediatric Spastic Paraplegia Type 4: A Case Study2025
Expanding Hereditary Spastic Paraplegias Limits: Biallelic <i>SPAST</i> Variants in Cerebral Palsy Mimics2025
A Case of Hereditary Spastic Paraplegia Type 50 With a Novel AP4M1 Variant and a Brief Review of the Literature2025

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