Biological Sex Influences the Clinical Phenotype of AD and FTD Spectrum Disorders (P5-13.008)

Kaitlyn Jang; Kristen Berendzen; Isabel Allen; Luke Fischer; Ezra Mauer; Marianne Chapleau; Maxime Montembeault; Kaitlin Casaletto; Virginia Sturm; William Seeley; Renaud LaJoie; Gil Rabinovici; Bruce Miller; Maria Luisa Gorno Tempini; Zachary Miller

doi:10.1212/wnl.0000000000216556

June 9, 2026Neurology

Biological Sex Influences the Clinical Phenotype of AD and FTD Spectrum Disorders (P5-13.008)

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Key Points

The aim is to understand how biological sex impacts the clinical manifestations of Alzheimer's disease and frontotemporal dementia.
Characterized biological sex ratios
Analyzed the clinical phenotype across a global population.
Utilized data from diverse geographic locations.
Identified distinct clinical phenotypes associated with biological sex in AD and FTD.
Found variations in disease presentation based on sex across the studied population.

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Implication

Characterizes biological sex ratios in Alzheimer's and frontotemporal dementia, indicating significant clinical implications.

Abstract

To characterize biological sex ratios within Alzheimer’s disease (AD) and frontotemporal dementia (FTD) spectrum disorders across a global population.

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Cite This Study

Jang et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3d6faef96ed7f056467 https://doi.org/10.1212/wnl.0000000000216556

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Biological Sex Influences the Clinical Phenotype of AD and FTD Spectrum Disorders (P5-13.008)

Key Points

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Implication

Abstract

Discussion

Cite This Study

Biological Sex Influences the Clinical Phenotype of AD and FTD Spectrum Disorders (P5-13.008)

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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