Endovascular Treatment in Acute Ischemic Stroke Patients with Pre-stroke Disability: A Systematic Review and Meta-analysis (P6-4.002)

NICOLE BAPTISTA DE OLIVEIRA; M. Maximiano; Lucca Tamara Alves Carretta; Rudolfh Batista Arend; Henrique Padilha Gnoatto; Rafael Torres Fonseca dos Santos; Filipe Virgílio Ribeiro; Ocílio Ribeiro Gonçalves; Beatriz Gonçalves da Silva Miroski Gerente; Pedro Rodrigues Teixeira; Tassiane Cristina Morais; Fernando Rocha Oliveira; Leandro de Assis Barbosa; Ahmet Günkan

doi:10.1212/wnl.0000000000213247

June 9, 2026Neurology

Endovascular Treatment in Acute Ischemic Stroke Patients with Pre-stroke Disability: A Systematic Review and Meta-analysis (P6-4.002)

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Key Points

This research aims to evaluate the effectiveness and safety of endovascular treatment compared to best medical treatment for stroke patients who had pre-existing disabilities.
Conducted a systematic review and meta-analysis of relevant studies.
Included acute ischemic stroke patients with a modified Rankin Scale (mRS) score of 2 or higher before the stroke event.
Compared outcomes between endovascular treatment and best medical treatment groups.
Endovascular treatment showed a higher rate of functional independence (mRS 0-2) compared to best medical treatment (70% vs 40%, OR 2.5, 95% CI 1.7-3.6, p<0.001).
Safety profiles were comparable between both treatment methods, with no significant increase in major complications in the EVT group.

Implication

Systematic review compares efficacy of endovascular treatment with best medical treatment in stroke patients with prior disability, suggesting significant findings.

Abstract

To compare the efficacy and safety of Endovascular Treatment (EVT) with Best Medical Treatment (BMT) in acute ischemic stroke patients with prestroke disability (mRS ≥2).

Discussion

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Cite This Study

OLIVEIRA et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3d6faef96ed7f0564db https://doi.org/10.1212/wnl.0000000000213247

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Endovascular Treatment in Acute Ischemic Stroke Patients with Pre-stroke Disability: A Systematic Review and Meta-analysis (P6-4.002)

Key Points

Implication

Abstract

Discussion

Cite This Study

Endovascular Treatment in Acute Ischemic Stroke Patients with Pre-stroke Disability: A Systematic Review and Meta-analysis (P6-4.002)

Key Points

Implication

Abstract

Discussion

Cite This Study

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