Correction of Age-dependent Mitochondrial Dysfunction via Autophagy Enhancement in Reprogrammed Human Neurons (P3-12.009)

Eva Klinman; Andrew Yoo

doi:10.1212/wnl.0000000000215682

June 9, 2026Neurology

Correction of Age-dependent Mitochondrial Dysfunction via Autophagy Enhancement in Reprogrammed Human Neurons (P3-12.009)

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Key Points

The aim is to investigate age-related mitochondrial dysfunction in reprogrammed human neurons and assess if enhancing autophagy can reverse these defects.
Evaluated mitochondrial behavior in directly reprogrammed human neurons.
Improved autophagy to assess its impact on aging phenotype.
Enhanced autophagy significantly improved mitochondrial health.
Rescue of aging phenotype was observed in treated neurons.

Implication

Evaluates mitochondrial health in reprogrammed human neurons, indicating autophagy's role in reversing aging effects.

Abstract

Evaluate age-associated changes in mitochondrial behavior and health in directly reprogrammed human neurons, and determine if improving defective autophagy rescues the aging phenotype.

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Cite This Study

Klinman et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3d6faef96ed7f05651f https://doi.org/10.1212/wnl.0000000000215682

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Correction of Age-dependent Mitochondrial Dysfunction via Autophagy Enhancement in Reprogrammed Human Neurons (P3-12.009)

Key Points

Implication

Abstract

Discussion

Cite This Study

Correction of Age-dependent Mitochondrial Dysfunction via Autophagy Enhancement in Reprogrammed Human Neurons (P3-12.009)

Key Points

Implication

Abstract

Discussion

Cite This Study

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