Diagnostic Accuracy of Glial Fibrillary Acidic Protein (GFAP) for Differentiating Ischemic Stroke from Intracerebral Hemorrhage: A Systematic Review and Meta-analysis (P7-4.001)

Faisal Aljamea; Nicholas Aderinto; Syed Hasham Ali; Temitomi Jane Oyedele; Emmanuel Egbunu; Gbolahan Olatunji; Emmanuel Kokori; Faith Adedayo Adejumo; Adetola Emmanuel Babalola

doi:10.1212/wnl.0000000000217196

June 9, 2026Neurology

Diagnostic Accuracy of Glial Fibrillary Acidic Protein (GFAP) for Differentiating Ischemic Stroke from Intracerebral Hemorrhage: A Systematic Review and Meta-analysis (P7-4.001)

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Key Points

This review aims to assess how well glial fibrillary acidic protein distinguishes between ischemic stroke and intracerebral hemorrhage.
Conducted a systematic review and meta-analysis of existing studies on GFAP.
Focused on studies involving adults with confirmed diagnoses of ischemic stroke or intracerebral hemorrhage.
Analyzed the diagnostic performance metrics of GFAP.
GFAP showed significant diagnostic accuracy differences between ischemic stroke and intracerebral hemorrhage.
The pooled sensitivity and specificity values indicated that GFAP can be a reliable biomarker.
Further statistical analysis highlighted GFAP's potential utility in acute clinical settings.

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Implication

Systematic review assesses GFAP's accuracy in differentiating ischemic stroke from intracerebral hemorrhage.

Abstract

To assess the diagnostic accuracy of glial fibrillary acidic protein (GFAP) for distinguishing intracerebral hemorrhage (ICH) from ischemic stroke (IS) in adults using systematic review and meta-analysis.

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Aljamea et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3d6faef96ed7f05654d https://doi.org/10.1212/wnl.0000000000217196

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Diagnostic Accuracy of Glial Fibrillary Acidic Protein (GFAP) for Differentiating Ischemic Stroke from Intracerebral Hemorrhage: A Systematic Review and Meta-analysis (P7-4.001)

Key Points

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Implication

Abstract

Discussion

Cite This Study

Diagnostic Accuracy of Glial Fibrillary Acidic Protein (GFAP) for Differentiating Ischemic Stroke from Intracerebral Hemorrhage: A Systematic Review and Meta-analysis (P7-4.001)

Key Points

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Implication

Abstract

Discussion

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