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June 9, 2026Neurology

Evaluating the Therapeutic Benefits of Naltrexone in ME/CFS and Long Covid Patients: A Systematic Literature Review (P9-2.002)

Karla Rodriguez Manso Marcos Saint-Felix

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Key Points

This review aims to synthesize existing research on low dose naltrexone for managing symptoms in ME/CFS and long COVID.
Conducted a systematic literature review of studies on low dose naltrexone
Focused on patient populations with ME/CFS and long COVID
Analyzed the therapeutic outcomes and symptom relief reported in the literature.
Found that low dose naltrexone may improve symptom management in ME/CFS and long COVID patients
Indications of reduced fatigue and pain were consistently reported
Further research is necessary to establish definitive efficacy and guidelines.

Implication

Systematic review evaluates naltrexone's effectiveness for symptom management in ME/CFS and long COVID, suggesting potential therapeutic use.

Abstract

Synthesize current data about using low dose Naltrexone in symptom management for ME/CFS and long COVID.

Discussion

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Cite This Study

Manso et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf403faef96ed7f0565e1 https://doi.org/10.1212/wnl.0000000000217363

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