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June 13, 2026New BiotechnologyOpen Access

Sustainable microbial production of retinol in Yarrowia lipolytica: From strain engineering to formulation

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Authors

SHS. S. HongDLDongpil LeeHKHyunwoo J. Kim

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Overview

Randomized trial demonstrates enhanced retinol production in Yarrowia lipolytica, suggesting efficient microbial synthesis for sustainability.

Key Points

  • This research aims to develop a sustainable method for producing retinol using engineered Yarrowia lipolytica.
  • Engineered Yarrowia lipolytica for retinol production.
  • Supplemented fermentation with Tween 20 and antioxidant BHT.
  • Developed an extraction strategy for retinol using n-hexane and ethanol.
  • Increased retinol production to 7.16g/L in a 5-L fermenter with 48.6% purity.
  • Achieved 3.2-fold enhancement in production through increased acetyl-CoA and pathway flux.
  • Validated a prototype formulation containing 10% retinol for cytotoxicity and stability.

Cite This Study

Hong et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf403faef96ed7f05663chttps://doi.org/10.1016/j.nbt.2026.06.003
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