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This case report aims to describe a unique instance of PML in an immunocompetent host and the effects of pembrolizumab treatment.

June 13, 2026Neurology

Progressive Multifocal Leukoencephalopathy in an Immunocompetent Host Treated with Pembrolizumab (P9-3.003)

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Case report describes clinical and radiological responses to pembrolizumab in immunocompetent PML patient, suggesting potential treatment options.

This case report aims to describe a unique instance of PML in an immunocompetent host and the effects of pembrolizumab treatment.
Descriptive case report of an immunocompetent patient with biopsy-proven PML.
Clinical and radiological assessments were conducted to evaluate treatment response.
The patient demonstrated a positive clinical response to pembrolizumab treatment.
Radiological imaging showed improvements following therapy.

Upadhyay et al. (2026) studied this question.

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Case report describes clinical and radiological responses to pembrolizumab in immunocompetent PML patient, suggesting potential treatment options.