This case report examines spinal cord injury from nitrous oxide misuse in a young adult, indicating a need for awareness.
Nitrous oxide (N2O) misuse is a growing cause of neurologic morbidity in young adults. N2O oxidizes and inactivates vitamin B12, disrupting myelin synthesis and resulting in subacute combined degeneration (SCD) of the spinal cord. Clinical features often mimic traumatic or compressive myelopathies, delaying recognition.
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Yasonova et al. (2026) studied this question.
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