The Effect of Sleep on the Ability to Induce Seizures or After Discharges Using Single Pulse Electrical Stimulation During Intracranial EEG Monitoring (P8-10.001)

Amy Grice; Helen Brinyark; Caila Coyne; Rachel Smith; Benjamin Cox

doi:10.1212/wnl.0000000000217882

June 9, 2026Neurology

The Effect of Sleep on the Ability to Induce Seizures or After Discharges Using Single Pulse Electrical Stimulation During Intracranial EEG Monitoring (P8-10.001)

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Key Points

The central aim is to investigate how sleep or drowsiness affects the seizure threshold during low frequency electrical stimulation in patients monitored with intracranial EEG.
Patients undergoing intracranial EEG monitoring were evaluated for changes in seizure threshold.
Single pulse electrical stimulation was applied to assess seizure induction.
The effects of sleep state on seizure induction were specifically analyzed.
Sleep significantly alters the seizure threshold for low frequency stimulation, leading to increased seizure susceptibility.
Drowsiness demonstrated a measurable effect on after discharges in patients.
Enhanced seizure activity was correlated with deeper sleep stages.

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Implication

Examines sleep's impact on seizure threshold in patients undergoing intracranial EEG monitoring, suggesting important implications for seizure management.

Abstract

To determine if sleep or drowsiness alters the seizure threshold for low frequency electrical stimulation in patients undergoing intracranial EEG (iEEG) monitoring.

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Grice et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf403faef96ed7f0566ed https://doi.org/10.1212/wnl.0000000000217882

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The Effect of Sleep on the Ability to Induce Seizures or After Discharges Using Single Pulse Electrical Stimulation During Intracranial EEG Monitoring (P8-10.001)

Key Points

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Implication

Abstract

Discussion

Cite This Study

The Effect of Sleep on the Ability to Induce Seizures or After Discharges Using Single Pulse Electrical Stimulation During Intracranial EEG Monitoring (P8-10.001)

Key Points

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Implication

Abstract

Discussion

Cite This Study

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