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June 13, 2026Neurology

Do SGLT2 Inhibitors Influence Parkinson’s Disease Risk? A Meta-analysis of Randomized Trials (P6-17.012)

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Authors

TATheres Boby AlexanderJRJamir Pitton RissardoACAna Leticia Fornari Caprara

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Overview

Meta-analysis evaluates SGLT2 inhibitors' effect on Parkinson’s disease risk in patients with specific conditions, suggesting potential implications.

Key Points

  • The aim is to assess the influence of SGLT2 inhibitors on the risk of developing Parkinson's disease in patients with various health conditions.
  • Conducted a meta-analysis of randomized trials examining SGLT2 inhibitors.
  • Included patients with diabetes, heart failure, or chronic kidney disease.
  • SGLT2 inhibitors may lower the risk of Parkinson’s disease compared to controls.
  • Specific metrics on event rates and statistical significance were found in the analysis.

Cite This Study

Alexander et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf403faef96ed7f056715https://doi.org/10.1212/wnl.0000000000213157
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1916-P: SGLT2 Inhibitors and Parkinson’s Disease (PD) Risk in Older Populations with Type 2 Diabetes (T2D)2024 · 3 citations
  2. 2Association Between SGLT2 Inhibitors and Risk of Dementia and Parkinson's Disease: A Meta-Analysis of 12 Randomized Controlled Trials2024 · 24 citations
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  4. 4920-P: Sodium–Glucose Cotransporter 2 Inhibitor Use and Risk of Dementia and Parkinson’s disease among Patients with Type 2 Diabetes—A Longitudinal, Nationwide, Population-Based Cohort Study2024
  5. 5Association of SGLT2 Inhibitors With Risk of Atrial Fibrillation and Stroke in Patients With and Without Type 2 Diabetes: A Systemic Review and Meta-Analysis of Randomized Controlled Trials.2022 · 39 citations