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June 13, 2026European Journal of Preventive CardiologyOpen Access

Chronic venous disease is associated with an increased risk of cardiovascular disease and mortality: evidence from a systematic review and meta-analysis totalling 13 studies and 6.4 million people

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Authors

LLL De LucaVBV Blanc-GuillemaudMOM B Onselaer

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Overview

Systematic review and meta-analysis reveal increased cardiovascular events and mortality linked to chronic venous disease in adults, suggesting the need for targeted interventions.

Key Points

  • This study investigates whether chronic venous disease (CVeD) is linked to an increased risk of cardiovascular events and mortality.
  • Conducted a systematic literature review following PRISMA guidelines, searching PubMed.
  • Included 13 studies involving 6.4 million participants, with a focus on cardiovascular outcomes in individuals with CVeD.
  • Utilized meta-analysis to pool hazard ratios (HR) and assess heterogeneity.
  • CVeD was associated with a 50% increased risk of cardiovascular events (HR=1.5 [1.1;2.0], p=0.004).
  • All-cause mortality risk was significantly higher, particularly in patients with moderate to severe CVeD (HR=1.3 [1.2;1.6], p<0.001).
  • Higher risk of coronary and heart diseases was noted (HR=1.3 [1.1;1.6], p=0.006), with high heterogeneity observed.

Cite This Study

Luca et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf403faef96ed7f05671dhttps://doi.org/10.1093/eurjpc/zwag249.115
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Also Consider

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