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June 13, 2026Hemoglobin

Compound Heterozygous Hemoglobin Minneapolis-Laos and Codon 41/42 (-TTCT) in a Thai Female Adult: A Case Report and Literature Review

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Authors

SPSitanun PreechathaveekidSiriraj HospitalTRTarinee RungjirajittranonSiriraj HospitalNCNuttiruetai ChanpoSiriraj Hospital

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Overview

Case report describes severe anemia from compound heterozygous β0-thalassemia and Hemoglobin Minneapolis-Laos, highlighting diagnostic challenges.

Key Points

  • The aim is to report a unique case of compound heterozygous β0-thalassemia and hemoglobin Minneapolis-Laos, emphasizing its clinical implications.
  • Case report of a 46-year-old Thai female at Siriraj Hospital with chronic microcytic anemia.
  • Hemoglobin electrophoresis and next-generation sequencing were utilized to identify genetic mutations.
  • Two specific mutations in the β-globin gene were characterized.
  • Initial hemoglobin A2 levels were elevated at 5.5% and 6.3%, indicative of β-thalassemia trait.
  • Identification of heterozygous β0-thalassemia codon 41/42 (-TTCT) and HBB c.356T >A associated with hemoglobin Minneapolis-Laos.
  • The combination presents a more severe phenotype than expected from either condition alone.

Cite This Study

Preechathaveekid et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf41ffaef96ed7f056816https://doi.org/10.1080/03630269.2026.2684611
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