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September 20, 2025Journal of Associated Medical Sciences

Case Report: Two cases of Hb Malay (HBB: c.59A>G) found in Northern Thailand

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Authors

MTMoe TheingiCRChedtapak RuengditMPManoo Punyamung

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Overview

Case report highlights anemia diagnosis challenges from Hb Malay and thalassemia in females.

Key Points

  • Both patients were diagnosed with variants of Hb Malay, indicating complexities in diagnosis.
  • Initial testing showed hypochromic microcytic anemia and elevated HbA2 levels typical of thalassemia.
  • Genetic analysis included next-generation sequencing and other hematological investigations.
  • Understanding Hb Malay's diagnosis is crucial for genetic counseling in thalassemia-prone areas.

Cite This Study

Theingi et al. (2025) studied this question.

synapsesocial.com/papers/68d46fcd31b076d99fa69ec2https://doi.org/10.12982/jams.2026.011
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization of Hemoglobin Malay Phenotypes in Tertiary Hospitals2024 · 2 citations
  2. 2The Importance of Molecular Biological Analysis for the Laboratory Diagnostic of Homozygous Haemoglobin Malay2024 · 1 citations
  3. 3Molecular Identification and Familial Segregation of the Hb Malay (HBB:c.59A>G) Variant in a Three-Generation Indonesian Family2026
  4. 4A systematic review of the prevalence and phenotypic characteristics of hemoglobin Malay in Southeast Asia2026
  5. 5Compound Heterozygous Hemoglobin Minneapolis-Laos and Codon 41/42 (-TTCT) in a Thai Female Adult: A Case Report and Literature Review2026