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This research aims to evaluate the impact of amyloid-beta fibrils on neuronal function and synaptic plasticity in Alzheimer’s disease.

Amyloid-beta fibrils as active contributors to synaptic dysfunction in Alzheimer’s disease

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This research aims to evaluate the impact of amyloid-beta fibrils on neuronal function and synaptic plasticity in Alzheimer’s disease.
Amyloid-beta fibrils were generated from Aβ 1-42 oligomers.
Effects on synaptic plasticity were assessed using ex vivo hippocampal slices from male and female mice.
A liposomal model was utilized to study ribil-membrane interactions.
Fibrils induced more severe damage to synaptic plasticity compared to Aβ 1-42 oligomers.
Aβ fibrils affected membrane fluidity, indicating their size and aggregation state are important for toxicity.
Data suggests that Aβ fibrils contribute to cognitive decline in Alzheimer's disease.

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Randomized trial investigates the effects of amyloid-beta fibrils on synaptic plasticity in mice, suggesting their role in cognitive decline.

Maisto et al. (2026) studied this question.

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Randomized trial investigates the effects of amyloid-beta fibrils on synaptic plasticity in mice, suggesting their role in cognitive decline.