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June 13, 2026The Journal of Basic and Applied ZoologyOpen Access

Insecticidal efficacy of Lippia adoensis Hochst extract and fractions on larvae and adults Anopheles gambiae Giles and chemical profiling of active fractions by UHPLC-MS/MS

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Authors

KMKalayam Kalayam MoutsinaTKThéodora Kopa KowaLYLame Younoussa

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Overview

Randomized trial evaluates insecticidal effects of Lippia adoensis on malaria vectors, suggesting potential as a bio-insecticide.

Key Points

  • This study aims to evaluate the insecticidal efficacy of Lippia adoensis extract against Anopheles gambiae larvae and adults and analyze active compounds.
  • Methanol extraction of L. adoensis leaf powder followed by column chromatography to obtain five fractions.
  • Efficacy tested on A. gambiae larvae and adults at concentrations ranging from 125 to 1000 ppm per WHO guidelines.
  • Chemical profiling performed using UHPLC-MS/MS to identify active compounds in extracts.
  • The methanol extract had strong larvicidal activity with an LC50 of 18.14 ppm.
  • Fraction F1 showed the highest adulticidal activity with an LC50 of 223.34 ppm after 24 hours.
  • Chemical analysis identified 19 compounds, with flavonoids being the major bioactive class.

Cite This Study

Moutsina et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf41ffaef96ed7f05694bhttps://doi.org/10.1186/s41936-026-00597-z
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Also Consider

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  5. 5Potential Repellent and Insecticidal Effects of Millipede-derived Secretions Against <i>Anopheles gambiae</i> s.l., the Main Malaria Vector in Africa2026