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June 13, 2026JCO Global OncologyOpen Access

Assessing the Diversity of Participants in US Colorectal Cancer Clinical Trials: A Comprehensive Review and Meta-Analysis

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Authors

HSH. SmithUniversity of Tennessee Health Science CenterSKSaad Khalid KhanOklahoma State University Center for Health SciencesJBJ. Tyler BabekOklahoma State University Center for Health Sciences

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Overview

Comprehensive review analyzes racial and sex representation in colorectal cancer clinical trials in the US, suggesting the need for equitable participant inclusion.

Key Points

  • The aim is to evaluate the diversity of participants in US colorectal cancer clinical trials and highlight disparities.
  • Conducted a systematic review and meta-analysis of CRC clinical trials published between 2018 and 2023.
  • Included studies were evaluated for age, race, sex, and ethnicity representation.
  • Generated a participation-to-disease representation ratio and scored representation as 'poor', 'fair', or 'good'.
  • Out of 25 clinical trials, 21 studies received a 'poor' rating for race and ethnicity representation.
  • Nine studies received a 'good' rating for sex representation, while seven received a 'poor' rating.
  • Overall, White populations were over-represented, with Asian, Black, and Hispanic populations under-represented.

Cite This Study

Smith et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf45afaef96ed7f056ad0https://doi.org/10.1200/go-25-00409
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