Investigates central neural reorganization predicting surgery outcome in trigeminal neuralgia, indicating the need for alternative treatments.
Microvascular decompression is the standard surgical intervention for classical trigeminal neuralgia attributed to neurovascular compression. However, up to 30% of patients experience poor outcomes despite technically successful surgery, suggesting non-peripheral mechanisms. This study investigates whether central neural reorganization—manifested as altered cortico-subcortical connectivity and white matter microstructure—underlies poor surgical outcomes in patients with “incidental” low-pressure vascular contact.
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Wang et al. (2026) studied this question.
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