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June 13, 2026BMC NephrologyOpen Access

Prognosis of critically ill patients with cirrhosis and acute kidney injury initiated on dialysis

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Authors

EKEric KernsBrown UniversityAAAhmed AgameyaLahey Hospital and Medical CenterAAAhmed AbdelfattahLahey Hospital and Medical Center

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Overview

Retrospective cohort analysis examines survival outcomes in critically ill cirrhosis patients receiving kidney therapy, suggesting limited prognosis.

Key Points

  • To evaluate the impact of acute kidney injury on survival in critically ill patients with cirrhosis requiring kidney replacement therapy.
  • Conducted a retrospective cohort analysis of patients with cirrhosis and AKI in a medical ICU.
  • Gathered data on CLIF-C ACLF and MELD-Na scores at ICU admission.
  • Analyzed survival outcomes at 1 and 6 months post-KRT initiation.
  • Only 21.4% and 15.3% of patients were alive at 1 and 6 months post-admission, respectively.
  • Median survival time from KRT initiation was 5 days (IQR 3-12.5 days).
  • Significant associations found with CLIF-C ACLF score and survival, rather than KRT modality.

Cite This Study

Kerns et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf488faef96ed7f056c41https://doi.org/10.1186/s12882-026-05096-5
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Also Consider

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  1. 1Epidemiology of Critically Ill Patients With Cirrhosis Undergoing Continuous Renal Replacement Therapy: A Contemporaneous Parallel Analysis of the HRS-HARMONY and CRRTnet Registries2026
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  3. 3Impact of acute kidney injury response on survival and liver transplant rates in hospitalized patients with cirrhosis awaiting liver transplantation: Results from the HRS-HARMONY consortium2024 · 3 citations
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