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June 13, 2026Genetics Selection EvolutionOpen Access

Genomic selection strategies and their potential to maintain rare alleles and de-novo mutations: a long-term assessment

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Authors

MSMatías F. SchraufJVJérémie VandenplasHMHerman A. Mulder

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Overview

Randomized trial evaluates genomic selection strategies to balance genetic gain and diversity management, suggesting enhanced sustainability.

Key Points

  • The aim is to assess genomic selection strategies for long-term genetic improvement while conserving rare alleles and de-novo mutations.
  • Simulated populations of 1000 individuals across 50 generations of selection.
  • Evaluated traits with different gene action types: additive, dominance, and epistatic.
  • Compared five genomic selection strategies focusing on genetic improvement and diversity management.
  • Allele-reweighted strategies improved both genetic variance and long-term gain compared to truncation selection.
  • Optimal contribution selection conserved more genetic variance with higher gain for traits with epistatic actions.
  • Constrained allele loss selection did not show benefits over truncation selection.

Cite This Study

Schrauf et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf488faef96ed7f056c4dhttps://doi.org/10.1186/s12711-026-01052-x
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