The impact of soft-tissue phantoms on the in vivo quantification of lead in bone using portable X-ray fluorescence spectrometry

Sajed Mcheik; Eric Da Silva; Ana Pejović‐Milić

doi:10.1039/d6ja00139d

January 1, 2026Journal of Analytical Atomic SpectrometryOpen Access

The impact of soft-tissue phantoms on the in vivo quantification of lead in bone using portable X-ray fluorescence spectrometry

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Key Points

This research aims to evaluate how soft-tissue phantoms affect the accuracy of measuring lead in bone using portable X-ray fluorescence techniques.
Used portable X-ray fluorescence spectrometry to measure bone lead levels.
Incorporated soft-tissue phantoms to simulate tissue interference during quantification.
Analyzed data to determine the impact of phantoms on accuracy.
Found that soft-tissue phantoms significantly alter the accuracy of lead quantification in bone.
Demonstrated that bone lead measurements vary with the presence of different tissue configurations.
Provided evidence supporting the need for adjusted calibration methods in pXRF analyses.

Implication

Assesses in vivo bone lead levels using pXRF, indicating the influence of soft-tissue phantoms.

Abstract

Portable X-ray fluorescence spectrometry (pXRF) has emerged as a promising technique for the in vivo quantification and monitoring of bone lead (Pb) through the detection of characteristic Pb L Xrays....

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Cite This Study

Mcheik et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf4aefaef96ed7f056f3c https://doi.org/10.1039/d6ja00139d

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The impact of soft-tissue phantoms on the in vivo quantification of lead in bone using portable X-ray fluorescence spectrometry

Key Points

Implication

Abstract

Discussion

Cite This Study

The impact of soft-tissue phantoms on the in vivo quantification of lead in bone using portable X-ray fluorescence spectrometry

Key Points

Implication

Abstract

Discussion

Cite This Study

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