OBJECTIVES: This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective To evaluate the benefits and harms of bone marrow-sparing radiotherapy compared with non-bone marrow-sparing radiotherapy in women with locally advanced cervical cancer treated with concurrent chemoradiotherapy. Secondary objectives To investigate whether effects differ according to clinical, histopathological, and technical characteristics, focusing on: acute haematologic toxicity; acute gastrointestinal and genitourinary toxicity; and bone marrow dose-volume parameters associated with acute haematologic toxicity, including exploration of dose-volume ranges relevant for clinical implementation.
Cantídio et al. (Thu,) studied this question.