Catalytic Enantioselective Access to N(III)-Stereogenic Aziridines via Chiral Brønsted Acid-Catalyzed N–Cl Bond Formation

Yuting Zheng; Minghong Liao; Gefei Hao; 金林红; Barana C Jayawardana; B Marambe; Qiang Xiong; Xingxing Wu

doi:10.1039/d6cc02512a

January 1, 2026Chemical Communications

Catalytic Enantioselective Access to N(III)-Stereogenic Aziridines via Chiral Brønsted Acid-Catalyzed N–Cl Bond Formation

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Key Points

The aim is to develop a method for the asymmetric synthesis of nitrogen-centered stereogenic aziridines.
Chiral phosphoric acid was used as a catalyst for the enantioselective reaction.
The method focuses on the formation of N–Cl bonds leading to aziridines.
Various conditions were optimized to enhance enantioselectivity.
The method achieved high enantioselectivity with the aziridines produced.
Yield percentages of products were reported to be significant, enhancing previous catalytic methods.

Implication

Demonstrates enantioselective synthesis of N-stereogenic aziridines, suggesting advances in asymmetric catalysis.

Abstract

The asymmetric construction of nitrogen-centered stereogenicity remains one of the longstanding challenges in asymmetric catalysis. Herein, we report an enantioselective synthesis of N-stereogenic aziridines through a chiral phosphoric acid-catalyzed asymmetric...

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Cite This Study

Zheng et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf4dafaef96ed7f0570d7 https://doi.org/10.1039/d6cc02512a

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Catalytic Enantioselective Access to N(III)-Stereogenic Aziridines via Chiral Brønsted Acid-Catalyzed N–Cl Bond Formation

Key Points

Implication

Abstract

Discussion

Cite This Study

Catalytic Enantioselective Access to N(III)-Stereogenic Aziridines via Chiral Brønsted Acid-Catalyzed N–Cl Bond Formation

Key Points

Implication

Abstract

Discussion

Cite This Study

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