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June 13, 2026Current Diabetes ReportsOpen Access

Efficacy and safety of once-weekly basal insulin analogs versus daily basal insulin analogs in adults with type 2 diabetes: a systematic review and meta-analysis

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Authors

DRDimitri A. RaptisSCSotirios ChiotisTPTheodoros Papamichalis

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Overview

Systematic review evaluates effects of once-weekly basal insulin on glycemic control in adults with type 2 diabetes, suggesting benefits for treatment adherence.

Key Points

  • This review investigates the effectiveness and safety of once-weekly basal insulin analogs compared to daily basal insulin in adults with type 2 diabetes.
  • Conducted a systematic review and meta-analysis of 14 randomized controlled trials (RCTs) with 8,487 subjects.
  • Compared the efficacy and safety of once-weekly basal insulin analogs to daily basal insulin analogs in terms of glycemic outcomes and hypoglycemia risk.
  • Evaluated outcomes including HbA1c levels and time in range (TIR).
  • Once-weekly basal insulin provided a greater reduction in HbA1c (mean difference -0.09%, 95% CI -0.15 to -0.03).
  • Improved time in range (TIR) observed with once-weekly insulin (mean difference 1.86%, 95% CI 0.73 to 2.98).
  • Higher odds of achieving HbA1c < 7.0% with once-weekly insulin (OR 1.32, 95% CI 1.07 to 1.63).

Cite This Study

Raptis et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf500faef96ed7f0571bfhttps://doi.org/10.1007/s11892-026-01628-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy and safety of once‐weekly basal insulin therapy in people with type 1 diabetes: A systematic review and meta‐analysis2025 · 2 citations
  2. 2Efficacy and safety of once-weekly insulin efsitora alfa versus daily basal insulin analogs in type 2 diabetes: a systematic review and meta-analysis2026
  3. 3Efficacy and Safety of Once‐Weekly and Once‐Daily Basal Insulins in Type 1 Diabetes Mellitus: A Systematic Review and Network Meta‐Analysis of Clinical Trials2026
  4. 4Once-Weekly Subcutaneous Insulin Efsitora for the Management of Diabetes Mellitus: A Systematic Review and Meta-Analysis Study2026
  5. 5Comparative Effectiveness of Once-Weekly Insulin Efsitora Alfa in Patients With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials2026