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January 1, 2026Nanoscale

Dual-Quenched and Redox-Responsive Gold Nanoplatforms for Tumor-Specific Multimodal Theranostics

Wen Zhou Nana Wang Chao Wang Huangchengzhi Zhang Zhiwei Xu Yuxin Huang Yuyan Zhang Chen Xie Quli Fan

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Key Points

This research aims to enhance the effectiveness of photodynamic therapy through targeted delivery using gold nanoplatforms.
Designed glutathione-responsive organic-inorganic gold nanoplatforms for targeted therapy.
Assessed the nanoplatforms' efficacy in photodynamic therapy for cancer treatment.
Evaluated tumor specificity and therapeutic outcomes using both in vitro and in vivo models.
Demonstrated improved therapeutic efficacy in tumor models with gold nanoplatforms compared to standard treatments.
Achieved targeted activation in tumor cells, reducing off-target effects significantly.
Notable enhancement in tumor reduction rates with p<0.05, indicating statistical significance.

Implication

Evaluates tumor-specific theranostics using responsive gold nanoplatforms, suggesting improved efficacy.

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Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf500faef96ed7f0571fe https://doi.org/10.1039/d6nr00464d

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Stimuli‐Responsive Nanoplatform for Photodynamic Therapy and Disulfidptosis SynergyOriginal Research · 2026
2Tumor targeted nanohybrid for dual stimuli responsive and NIR amplified photothermal/photo-induced thermodynamic/chemodynamic combination therapy2024 · 4 citations
3A dual-targeted hyaluronic acid-gold nanorod platform with triple-stimuli responsiveness for photodynamic/photothermal therapy of breast cancerOriginal Research · 2018 · 177 citations
4Glutathione responsive nanomedicine leverages tumor redox imbalance for targeted cancer theranosticsReview · 2026 · 16 citations
5An Anthracenyl‐Functionalized Boron Dipyrromethene Based Glutathione‐Responsive Nanoplatform for Efficient Photodynamic Therapy Enhanced by Perfluorooctanoic AcidOriginal Research · 2026

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