What question did this study set out to answer?

To develop a dual-targeted, triple-stimuli-responsive gold nanorod platform for fluorescence imaging-guided combined photodynamic and photothermal therapy of HER2-overexpressing breast cancer.

November 19, 2018Acta BiomaterialiaOpen Access

A dual-targeted hyaluronic acid-gold nanorod platform with triple-stimuli responsiveness for photodynamic/photothermal therapy of breast cancer

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To develop a dual-targeted, triple-stimuli-responsive gold nanorod platform for fluorescence imaging-guided combined photodynamic and photothermal therapy of HER2-overexpressing breast cancer.
Synthesized GNR-HA−ALA/Cy7.5-HER2 nanoplatforms by functionalizing gold nanorods with hyaluronic acid, 5-aminolevulinic acid, Cy7.5 dye, and anti-HER2 antibodies via Au-S bonds.
Assessed in vitro cellular uptake, reactive oxygen species production, and photothermal cytotoxicity in MCF-7 cells under near-infrared irradiation.
Evaluated pharmacokinetics, biodistribution, and therapeutic tumor suppression in vivo following fluorescence imaging-guided phototherapy.
Dual-targeting of HER2 and CD44 significantly increased cellular uptake and facilitated drug release responsive to pH, glutathione, and hyaluronidase.
Nanoplatforms demonstrated a circulation half-life of 1.9 h and achieved a tumor tissue accumulation ratio of 12.8%.
Near-infrared-triggered dual phototherapy completely eliminated tumors without noticeable side effects, outperforming photodynamic or photothermal monotherapies.

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Implication

Preclinical evaluation demonstrates complete tumor eradication using dual-targeted gold nanorods in breast cancer models, highlighting the therapeutic synergy of combined phototherapy.

Cite This Study

Xu et al. (2018) studied this question.

synapsesocial.com/papers/6a779c68f6b553d308ae9d90 https://doi.org/10.1016/j.actbio.2018.11.026

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Implication

Preclinical evaluation demonstrates complete tumor eradication using dual-targeted gold nanorods in breast cancer models, highlighting the therapeutic synergy of combined phototherapy.

A dual-targeted hyaluronic acid-gold nanorod platform with triple-stimuli responsiveness for photodynamic/photothermal therapy of breast cancer

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Discussion

Implication

Cite This Study

A dual-targeted hyaluronic acid-gold nanorod platform with triple-stimuli responsiveness for photodynamic/photothermal therapy of breast cancer

Key Points

Discussion

Implication

Cite This Study

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