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June 13, 2026World Journal for Pediatric and Congenital Heart Surgery

Perioperative Normoxia Versus Hyperoxia in Cyanotic Congenital Heart Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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Authors

LGL GoncalvesUniversidade Federal de UberlândiaLDLucas Monteiro DelgadoUniversidade Federal de Minas GeraisRORachid Eduardo Noleto da Nóbrega OliveiraHospital de Câncer de Barretos

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Overview

Systematic review compares normoxic and hyperoxic strategies during cardiopulmonary bypass in children, suggesting similar outcomes.

Key Points

  • To compare perioperative normoxic versus hyperoxic strategies during cardiopulmonary bypass in children with cyanotic congenital heart disease.
  • Systematic review and meta-analysis of randomized controlled trials.
  • Literature search in MEDLINE, Embase, and Cochrane Library.
  • Used random-effects models to pool risk ratios and mean differences; risk of bias assessed with RoB 2 tool.
  • Five trials with 241 children analyzed; 121 received normoxia and 120 hyperoxia.
  • No significant differences in all-cause mortality (RR 1.31; 95% CI 0.37-4.67; P = 0.67).
  • Postoperative recovery outcomes, including ICU stay and ventilation time, were comparable between groups.

Cite This Study

Goncalves et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf500faef96ed7f057224https://doi.org/10.1177/21501351261449205
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