Case report describes hyperammonemia and hepatic encephalopathy in a patient post hepatectomy, suggesting improved awareness is needed.
Hepatic encephalopathy after liver surgery is an uncommon but serious complication. In this context, we describe an unusual case of a patient with a history of uretero-sigmoidostomy who developed severe hepatic encephalopathy following hepatectomy for liver metastases of colorectal cancer. Mechanical ventilation, ammonia-lowering drugs and continuous veno-venous hemofiltration were required in order to reverse encephalopathy. It is hypothesized that ammonia reabsorption via the uretero-sigmoidostomy played a pivotal role in the clinical course of this patient. This report highlights the need for awareness for reabsorption of ammonia in case of a ureterosigmoidostomy in order to avoid unnecessary complications.
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Koning et al. (2026) studied this question.
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