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June 13, 2026Depression and AnxietyOpen Access

Distinct Trajectories of Amygdala Connectivity Patterns Characterize Remission vs. Non‐Remission in Patients With Major Depressive Disorder

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Authors

SZShudong ZhangZZZhifang ZhangXLXiaoya Li

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Overview

Randomized trial investigates amygdala connectivity patterns predicting treatment outcomes in depression, suggesting individualized therapy strategies.

Key Points

  • This study aims to explore how the connectivity of the amygdala relates to the effectiveness of antidepressant treatments in individuals with major depressive disorder.
  • Forty-eight patients with major depressive disorder underwent multiple resting-state fMRI scans.
  • Patients were categorized into remission (MDDr) and nonremission (MDDnr) groups based on their treatment outcomes.
  • Changes in amygdala connectivity were analyzed in relation to symptom severity and treatment response.
  • At baseline, rsFC between the right basolateral amygdala and the right supplementary motor area was lower in MDDr and higher in MDDnr compared to healthy controls.
  • Distinct trajectories in rsFC were observed between MDDr and MDDnr groups, with normalization at 2 and 8 weeks post-treatment.
  • Baseline rsFC showed a relationship with treatment response, while longitudinal changes correlated with symptom improvement, though not all findings were statistically significant.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf500faef96ed7f057330https://doi.org/10.1155/da/4701907
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Resting-State Functional Connectivity of the Fronto-Limbic and Default Mode Networks as Predictors of Antidepressant Response in Major Depressive Disorder2025
  2. 2Amygdala subregional functional connectivity in Treatment-Resistant Depression2024 · 1 citations
  3. 3Default Mode Network Reconfiguration Underlies Clinical Response to Amygdala-Targeted Neuromodulation in Major Depression2025
  4. 4Longitudinal amygdala resting state functional connectivity develops differently in adolescents with internalising disorders compared to healthy peers2024
  5. 5The Role of Subgenual Resting-State Connectivity Networks in Predicting Prognosis in Major Depressive Disorder2024 · 5 citations