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June 13, 2026Open Access

Advances in Inductively Coupled Plasma–mass Spectrometry (Icp-Ms) for Bioanalytical Research: Applications, Challenges, and Future Perspectives – A Review

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Review highlights advancements and challenges in ICP-MS applications, indicating its growing importance in bioanalytical studies.

This review summarizes the advancements in inductively coupled plasma-mass spectrometry (ICP-MS) for bioanalytical applications.
Focused on the basic concepts of ICP-MS, including ionization, instrumentation, and detection methods.
Discussed new technologies enhancing ICP-MS performance, such as high-resolution systems and collision cells.
Highlighted sample preparation methods including acid digestion and contamination control.
Identified major uses of ICP-MS in trace element analysis, metallomics, and clinical diagnostics.
Addressed challenges like spectral interferences and matrix effects, offering insights on overcoming them.
Emphasized the potential of single-cell ICP-MS and nanoparticle analysis in future biomedical and environmental research.

Tamilselvi N.*, Dhayananthan M., Rajasekaran A., Ponnilavarasan I., Thiruvengadarajan V. S., Sridhar S. (2026) studied this question.

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June 13, 2026Open Access

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Authors

Review highlights advancements and challenges in ICP-MS applications, indicating its growing importance in bioanalytical studies.

This review summarizes the advancements in inductively coupled plasma-mass spectrometry (ICP-MS) for bioanalytical applications.
Focused on the basic concepts of ICP-MS, including ionization, instrumentation, and detection methods.
Discussed new technologies enhancing ICP-MS performance, such as high-resolution systems and collision cells.
Highlighted sample preparation methods including acid digestion and contamination control.
Identified major uses of ICP-MS in trace element analysis, metallomics, and clinical diagnostics.
Addressed challenges like spectral interferences and matrix effects, offering insights on overcoming them.
Emphasized the potential of single-cell ICP-MS and nanoparticle analysis in future biomedical and environmental research.

Tamilselvi N.*, Dhayananthan M., Rajasekaran A., Ponnilavarasan I., Thiruvengadarajan V. S., Sridhar S. (2026) studied this question.

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