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June 13, 2026Journal of VirologyOpen Access

A neutralizing nanobody targeting a conserved lateral patch on HA1 confers protection against multiple H7 avian influenza viruses

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Authors

SXSiqi XuFujian Medical UniversityQZQinying ZhangSouth China Agricultural UniversityXXXueer XieSouth China Agricultural University

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Overview

Randomized trial finds Nb74 confers protection against multiple H7 avian influenza viruses, indicating its therapeutic potential.

Key Points

  • This research aims to identify and evaluate a nanobody (Nb74) that can neutralize multiple H7 avian influenza viruses (AIVs).
  • Identified nanobodies targeting HA1 using yeast two-hybrid screening.
  • Validated hemagglutination inhibition and microneutralization activity of six candidates.
  • Conducted mouse challenge experiments with intratracheal administration of Nb74.
  • Nb74 showed HI-IC 50 values ranging from 0.23 to 43.75 µg/mL against H7 strains.
  • Achieved 100% and 80% survival in mice against specific strains at therapeutic doses.
  • Mapped the binding epitope of Nb74 to a conserved lateral patch on the HA1 subunit.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf551faef96ed7f0576d1https://doi.org/10.1128/jvi.00563-26
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