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June 13, 2026Cell & BioscienceOpen Access

CRISPR diagnostics: from trans-nuclease activity to cancer diagnosis

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Authors

LCLei ChangUniversity of California, San DiegoWXWenjue XuFirst Affiliated Hospital Zhejiang UniversityXWX T WangFirst Affiliated Hospital Zhejiang University

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Overview

Review chronicles the evolution of CRISPR diagnostics, demonstrating its application for cancer diagnosis, indicating significant advances.

Key Points

  • This review aims to explore the evolution of CRISPR diagnostics and its applications in cancer diagnosis.
  • Evaluation of CRISPR diagnostic workflow comprising target recognition, signal transduction, and signal readout.
  • Review of advancements in sensitivity and specificity for cancer diagnostics.
  • Discussion of technical limitations and potential solutions in CRISPR diagnostics.
  • Recent advancements have enabled attomolar-level detection and single-nucleotide discrimination in cancer diagnostics.
  • CRISPR diagnostics can identify nucleic acid biomarkers and non-nucleic acid biomarkers effectively.
  • Technical challenges include PAM sequence restriction and unmet needs for point-of-care testing in complex biological matrices.

Cite This Study

Chang et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf57cfaef96ed7f05776dhttps://doi.org/10.1186/s13578-026-01603-1
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