The Role of Hyaluronic Acid in Bone Regenerative Procedures in Dentistry: A Scoping Review

Hyaluronic acid (HA) has been increasingly used in dentistry as a biomaterial in bone regenerative procedures due to its properties related to tissue healing and regeneration. The aim of this scoping review was to outline and summarize the clinical literature on the use of HA in dental bone regeneration, focusing on indications, application approaches and reported outcomes. The review was conducted in accordance with PRISMA-ScR guidelines and the PCC framework and included clinical studies in adult patients in which HA was applied either alone or in combination with graft materials. A search of PubMed and the Cochrane Library was performed for studies published between 2000 and 2025, and article selection was based on predefined criteria. The reviewed literature shows heterogeneity in HA formulations, concentrations and application techniques, which limits direct comparison across studies. Most reported outcomes relate to radiographic or volumetric bone changes and healing-related parameters, while sample sizes are often small. Overall, hyaluronic acid appears to be a safe adjunct in dental bone regenerative treatments, but further clinical studies with clearer design and reporting are required to better define its clinical use.