Evaluates the effectiveness of bicyclo[2.2.2]oct-2-enes in bioisostere design, indicating a promising alternative to traditional methods.
The limited availability of polycyclic hydrocarbon scaffolds that accurately mimic the torsional angles of polysubstituted benzenes poses a challenge in bioisostere design. To address this issue, we propose bicyclo[2.2.2]oct-2-enes as...
No takes yet. Share an insight, caveat, or question.
Hsu et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: