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June 13, 2026PharmaceuticsOpen Access

Bioguided Isolation of (E)-Ethyl-12-cyclohexyl-4,5-dihydroxydodec-2-enoate from the Aerial Parts of Heliotropium indicum and Evaluation of Its Mechanism of Action Using the Formalin Test

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Authors

MSMaría Elena Sánchez‐MendozaJAJesús ArrietaYLYaraset López‐Lorenzo

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Overview

Randomized trial evaluates antinociceptive effects in mice from Heliotropium indicum, suggesting a nitric oxide pathway involvement.

Key Points

  • This research aims to identify the antinociceptive constituents of Heliotropium indicum and evaluate their mechanisms of action.
  • Evaluated three extracts of Heliotropium indicum using the formalin test in male Swiss albino CD-1 mice.
  • Fractionated the most active extract for antinociceptive screening of major fractions.
  • Investigated the involvement of several pathways with antagonist pretreatments.
  • Dichloromethane extract showed the broadest antinociceptive activity during phase II of the formalin test.
  • ECDE produced a dose-dependent effect with a DE50 of 0.76 mg/kg, compared to ketorolac.
  • Pretreatment with L-NAME and ODQ significantly reduced the effect of ECDE, indicating dependency on the NO–sGC pathway.

Cite This Study

Sánchez‐Mendoza et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf5aefaef96ed7f057928https://doi.org/10.3390/pharmaceutics18060714
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