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June 13, 2026Critical Reviews in ToxicologyOpen Access

Screening for the ovarian toxicity of industrial chemicals – ovarian follicles and corpora lutea counts in rats, an inter- and intra-laboratory comparison

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Authors

OKOlena KucheryavenkoKAKarine AngeliVBVincent Bonnomet

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Overview

Randomized trial evaluates ovarian toxicity assessment methods in rats, suggesting improved measurement consistency is essential.

Key Points

  • The study aims to assess methodologies for counting ovarian follicles and corpora lutea in reproductive toxicity studies and analyze variability.
  • Assembled and analyzed 73 Extended One-Generation Reproductive Toxicity (EOGRT) studies
  • Compared quantitative follicle and CL count methods
  • Evaluated sources of variability in counting procedures
  • 97% of studies performed quantitative follicle enumeration
  • 59% of studies conducted quantitative evaluation of CL
  • Median percentage coefficient of variation (%CV) for primordial follicles was 36% and for CL was 29%

Cite This Study

Kucheryavenko et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf5aefaef96ed7f057955https://doi.org/10.1080/10408444.2026.2664517
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