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June 13, 2026OphthalmologyOpen Access

Polygenic risk impacts lifetime risk and prognosis of glaucoma

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Authors

ETEemeli S. TusaUniversity of HelsinkiMTMax TamlanderUniversity of HelsinkiSamuli RipattiSamuli RipattiPreventive Cardiology

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Implication

Cohort study assesses glaucoma risk and prognosis via polygenic risk scores, suggesting new management strategies.

Key Points

  • To evaluate the clinical utility of a polygenic risk score (PRS) for assessing glaucoma.
  • Analyzed 402,739 individuals from FinnGen, with 21,609 diagnosed with glaucoma after age 40.
  • Benchmarking of 14 published glaucoma PRSs using Cox proportional hazards models.
  • Used Kaplan-Meier survival analyses to evaluate lifetime glaucoma risk and prognostic outcomes over 20 years.
  • Best-performing PRS had a hazard ratio of 3.32 (95% CI 3.21-3.43) for glaucoma risk.
  • Lifetime glaucoma risk rose from 2.5% in the <1st percentile to 45.3% in the ≥99th percentile.
  • Higher PRS decile patients showed significantly increased need for medications (60.6%), laser therapies (39.8%), and surgeries (15.8%) compared to lower deciles.

Cite This Study

Tusa et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf5aefaef96ed7f057a1fhttps://doi.org/10.1016/j.ophtha.2026.06.003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Clinical Usefulness of a Glaucoma Polygenic Risk Score in 4 Population-Based European Ancestry Cohorts2024 · 29 citations
  2. 2Genetics of glaucoma2017 · 391 citations
  3. 3The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma: a systematic review and economic evaluation2007 · 552 citations
  4. 4Systematic comparison of family history and polygenic risk across 24 common diseases2022 · 185 citations
  5. 5Price tag of glaucoma care is minor compared with the total direct and indirect costs of glaucoma: Results from nationwide survey and register data2023 · 7 citations