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June 13, 2026ChemistryOpen Access

Low-Molecular-Weight Versus Protein Inhibitors for the CXCL8/Glycosaminoglycan Interaction: Biophysical Characterization and Cellular Activity

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Authors

TGTanja GerlzaPPPaula PeinsippBMBirgit Müller

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Overview

Randomized trial evaluates binding effects of novel compounds on neutrophil recruitment in inflammatory conditions, suggesting new anti-inflammatory treatments.

Key Points

  • This research aims to compare low-molecular-weight inhibitors with protein inhibitors targeting the CXCL8/glycosaminoglycan interaction.
  • Synthesis of polyketide-pyrone compounds PA501 and PA502
  • Evaluation of binding affinities using filter binding assays
  • Transmigration assays to assess neutrophil mobilization and migration effects
  • PA501 and PA502 showed higher binding affinities to CXCL8 compared to heparan sulfate
  • PA501 exhibited the highest competition efficacy in displacing heparan sulfate from CXCL8
  • Both compounds modulated CXCL8-induced neutrophil migration in a dose-dependent manner

Cite This Study

Gerlza et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf665faef96ed7f05823ahttps://doi.org/10.3390/chemistry8060080
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of a Potent, Selective Non-peptide CXCR2 Antagonist That Inhibits Interleukin-8-induced Neutrophil Migration1998 · 432 citations
  2. 2Structural Basis of Chemokine CXCL8 Monomer and Dimer Binding to Chondroitin Sulfate: Insights into Specificity and Plasticity2026 · 4 citations
  3. 3Solution Structures of Glycosaminoglycan-bound CXCL8 Complexes Determined by Small-Angle X-Ray Scattering (SAXS)2026
  4. 4Rules of engagement: determinants of chemokine receptor activation and selectivity by CCL27 and CCL282025 · 1 citations
  5. 5Biophysical characterization of the CXC chemokine receptor 2 ligands2024 · 3 citations