Design Synthesis and Evaluation of New Azole as Anti-fungal Agents

A B S T R A C T The study was based on the design, synthesis and evaluation of new azole as antifungal agents. After design and synthesis, the novel Azole derivatives, these were characterized the synthesized novel Azole derivatives using following parameters i.e., physical appearance, melting point, TLC (Rf values), FTIR analysis, NMR analysis and Mass spectroscopy. To evaluate the anti-fungal potential of novel Azole (1,3,4-Oxadiazole) derivatives activity through well diffusion method against fungal strains i.e., Aspergillus niger, Penicillium notatum, Candida albicans and Rhizopus species. Zone inhibition (anti-fungal activity) of Oxadiazole (C4) was recorded as 4.86 mm, 5.27 mm, 5.49 mm, and 6.34 mm in S. aureus, A. niger, E. coli and C. albicans, respectively. It can be concluded that the anti-fungal potential was much significant against Rhizopus species which proves its anti-fungal action. Its anti-fungal potential might be due to the destruction of cell wall and/ nucleic acid of diverse fungal species. Ketoconazole as std. anti-fungal agent exhibited highest inhibition zone ranging from 12.0 to 24.0 mm. It also showed highest zone inhibition against Rhizopus species as 24.0 mm.