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This study aims to explore how electroacupuncture ameliorates neuronal injury and regulates blood pressure in spontaneously hypertensive rats.

Electroacupuncture Ameliorates RVLM Neuronal Injury in Spontaneously Hypertensive Rats via PI3K/Akt Pathway: Insights From Transcriptomic Analysis

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Randomized trial evaluates electroacupuncture effects on neuronal injury in hypertensive rats, indicating potential therapeutic benefits.

This study aims to explore how electroacupuncture ameliorates neuronal injury and regulates blood pressure in spontaneously hypertensive rats.
Four groups: WKY rats, spontaneously hypertensive rats (SHR), EA-treated SHRs, and a sham control.
Electroacupuncture applied at specific acupoints (LI11 and LR3) over 15 days; blood pressure and heart rate monitored.
Transcriptomic profiling conducted with RNA sequencing and qPCR; pathway analysis through GO and KEGG.
EA administration significantly decreased systolic blood pressure and cardiac rate in SHR.
Histological analysis showed improved neuronal morphology in the RVLM after EA, with reduced plasma Ang II and norepinephrine levels.
384 DEGs identified; 15 were adjusted towards normal levels after EA treatment, confirming the involvement of the PI3K/Akt pathway.

Yue et al. (2026) studied this question.

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