What question did this study set out to answer?

Develop and validate clinical rules for safer antimicrobial dosing in patients with renal impairment.

A Clinical Decision Support System to Optimize Antimicrobial Dosing in Patients with Renal Impairment

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Randomized trial demonstrates improved antimicrobial dosing in renal impairment, indicating safer medication use.

Develop and validate clinical rules for safer antimicrobial dosing in patients with renal impairment.
Developed clinical rules through literature review and expert consensus.
Integrated the rules into a clinical decision support system with electronic prescribing and health records.
Conducted a 9-week pilot validation study in a tertiary care hospital.
Generated 409 alerts for 249 patients, with 352 alerts (86%) reviewed by pharmacists.
Pharmacists intervened on 190 alerts (54%), with 111 interventions (71%) accepted by physicians.
Achieved an overall positive predictive value of 0.32, with acceptance rates from 57% to 80% across settings.

Garcia-Souto et al. (2026) studied this question.

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