Supervised Resistance Training in an Individual With Glioblastoma Undergoing Chemoradiation: A Case Report

Introduction: Exercise has demonstrated safety and efficacy in mitigating treatment-related symptoms across cancer populations; however, evidence in neuro-oncology remains limited, particularly during active chemoradiation. Methods: We report the case of a 63-year-old individual with newly diagnosed glioblastoma, experiencing symptoms of fatigue, balance issues, headaches, and memory loss, who initiated a 12-week supervised resistance training program during concurrent chemoradiation. Assessments at baseline and post-intervention included physical function and quality-of-life outcomes. Results: Adherence was 56% (20/36 sessions), and no adverse events occurred. The patient showed improvements in 6-minute walk distance and short physical performance battery score that exceeded established minimal clinically important differences. Quality-of-life findings were mixed, with certain domains benefiting from the exercise intervention and others worsening. Discussion: This case highlights the feasibility and safety of supervised resistance training during active glioblastoma chemoradiation. The observed improvements in physical function and select quality-of-life domains represent exploratory signals that compare favorably with the extant exercise oncology literature.