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June 13, 2026World Journal of PediatricsOpen Access

Impact of pathogen co-detection on disease severity and clinical outcomes in children with Mycoplasma pneumoniae pneumonia

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Authors

FWFeng WangYWYingwen WangYWYì Wáng

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Overview

Retrospective cohort study finds pathogen co-detection worsens disease severity in children with Mycoplasma pneumoniae pneumonia, suggesting enhanced diagnostic practices are needed.

Key Points

  • This research aims to assess the clinical impact of respiratory pathogen co-detection on disease severity in children with Mycoplasma pneumoniae pneumonia.
  • Retrospective cohort study of 3081 children hospitalized with confirmed Mycoplasma pneumoniae pneumonia.
  • Patients classified into mono-infection and co-detection groups based on respiratory pathogen testing.
  • Multivariable logistic regression used to analyze the association of co-detection with severe pneumonia outcomes.
  • Co-detection rate was 61.9%, with single-viral detections being most common (41.8%).
  • The co-detection group had a higher incidence of severe MPP (51.8% vs. 47.3%, P = 0.018) and longer hospital stays.
  • Pathogen co-detection was an independent risk factor for severe MPP with an adjusted odds ratio of 1.31 (95% CI = 1.11–1.56, P = 0.002).

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf6d7faef96ed7f058763https://doi.org/10.1007/s12519-026-01053-2
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  5. 5Clinical Characteristics and Early Risk Factors for Severe Mycoplasma Pneumoniae Pneumonia in Hospitalized Children: A Retrospective Analysis of 417 Cases2026