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June 13, 2026RSC Medicinal Chemistry

Targeting Hexokinase 2 for Cancer Therapy: Advances, Limitations, and Emerging Opportunities in Inhibitors and Degraders

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Authors

XWXianglong WangBLBaohu LiWYWei-Wei Yao

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Overview

Review highlights advances in targeting hexokinase 2 in cancer metabolism, suggesting future therapeutic possibilities.

Key Points

  • To assess the role of hexokinase 2 in cancer therapy and explore new strategies targeting this enzyme.
  • Reviewed recent strategies targeting hexokinase 2, including inhibitors and degraders.
  • Analyzed the limitations and effectiveness of current therapies aimed at HK2.
  • Identified several promising HK2 inhibitors that enhance cancer cell death.
  • Discussed limitations of existing therapies, indicating a need for novel approaches.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf6d7faef96ed7f05877dhttps://doi.org/10.1039/d6md00103c
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