C3-H Methylenephosphonylation of Azaarenes Enabled by Catalyst-controlled Regioselective Cyclizative Rearrangement

Dan Liu; Li Fang-Zhou; Yu-Ping He; Hua Wu

doi:10.1039/d6sc03456j

January 1, 2026Chemical ScienceOpen Access

C3-H Methylenephosphonylation of Azaarenes Enabled by Catalyst-controlled Regioselective Cyclizative Rearrangement

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Key Points

The aim is to enable the incorporation of phosphonate groups into azaarenes through C-H functionalization.
Utilized a catalyst-controlled regioselective cyclizative rearrangement process.
Performed intermolecular reactions to facilitate C-H functionalization.
Investigated the synthetic challenges involved in incorporating phosphonates.
Successfully incorporated phosphonate moieties into azaarenes with high regioselectivity.
Achieved notable efficiency in C-H functionalization under controlled catalytic conditions.
Demonstrated the potential for broader applications in pharmaceutical research.

Implication

Intermolecular cyclizative rearrangements enable phosphonate incorporation in azaarenes, suggesting new pathways for pharmaceutical synthesis.

Abstract

The incorporation of phosphonate moieties into azaarenes via C-H functionalization is of paramount importance in pharmaceutical research, yet it remains a formidable synthetic challenge. Herein, we report an intermolecular cyclizative...

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf6d7faef96ed7f0587cf https://doi.org/10.1039/d6sc03456j

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C3-H Methylenephosphonylation of Azaarenes Enabled by Catalyst-controlled Regioselective Cyclizative Rearrangement

Key Points

Implication

Abstract

Discussion

Cite This Study

C3-H Methylenephosphonylation of Azaarenes Enabled by Catalyst-controlled Regioselective Cyclizative Rearrangement

Key Points

Implication

Abstract

Discussion

Cite This Study

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