Key result
Opioid-free anesthesia reduces PONV by ~48% versus opioid-based anesthesia in gynecological surgery.
Why the study?
Postoperative nausea and vomiting remains common after gynecological surgery, and conclusions regarding whether opioid-free anesthesia minimizes these adverse reactions have been inconsistent.
Does opioid-free anesthesia reduce postoperative nausea and vomiting in patients undergoing gynecological surgery?
Comparison
Opioid-free anesthesia vs control
Design
Systematic review and meta-analysis
Authors
Loading...
Supports opioid-free anesthesia to reduce PONV; confirms efficacy and extends evidence for opioid-sparing strategies.
Meta-Analysis (n=514)
Does opioid-free anesthesia reduce postoperative nausea and vomiting in patients undergoing gynecological surgery?
Relative Risk: 0.52 (95% CI 0.4–0.66)
p-value: p=<0.00001
Opioid-free anesthesia reduces postoperative nausea and vomiting and antiemetic use, and improves recovery quality after gynecological surgery, but does not improve pain scores or extubation time.
Zhang et al. (2024) conducted a meta-analysis in Gynecological surgery (n=514). Opioid-free anesthesia vs. Opioid-based anesthesia was evaluated on Incidence of postoperative nausea and vomiting (PONV) (RR 0.52, 95% CI 0.40-0.66, p=<0.00001). Opioid-free anesthesia significantly reduced the incidence of postoperative nausea and vomiting (RR 0.52) compared to opioid-based anesthesia in patients undergoing gynecological surgery.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: