Biological Activity of Quaternary Ammonium Salts Containing 1,3-Dioxolane or gem-Dichlorocyclopropane Fragment

Quaternary ammonium salts (QASs) containing gem-dichlorocyclopropane and 1,3-dioxacycloalkane fragments were prepared in 40–90% yields based on pyridine, hexamethylenetetramine, and tertiary amines. The structures of the obtained salts were identified by 1H and 13C NMR spectroscopy. The antibacterial activity of QAS against a bacterial strain (Escherichia coli, Klebsiella pneumoniae, S. aureus, and Acinobacter Baumanii) were assessed. Among the salts tudied, leader compounds were identified that exhibited high antibacterial activity.