What does this research mean for the field?

Mechanical stress promotes macrophage polarization toward the M2 phenotype, suppresses glycolytic metabolic reprogramming, and enhances pro-angiogenic function by activating the SOCS3/STAT3 pathway via the upregulation of Integrin Subunit Alpha D (ITGAD). Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study aims to explore how mechanical stress affects macrophage polarization and metabolic processes in a pulmonary context.

June 14, 2026Cellular SignallingOpen Access

Mechanical stress attenuates the metabolic reprogramming and M1 polarization of macrophages by upregulating integrin subunit alpha D

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The study aims to explore how mechanical stress affects macrophage polarization and metabolic processes in a pulmonary context.
Examined the effects of 10% amplitude mechanical stress on RAW264.7 cells.
Conducted transcriptomic analyses to assess changes in gene expression.
Explored the role of integrin subunit alpha D in the SOCS3/STAT3 signaling pathway.
Mechanical stress significantly downregulated M1 markers (CD86, IL-1β, iNOS, TNF-α) while upregulating M2 markers (TGF-β, CD206, IL-10).
Glycolytic enzymes (PKM2, GLUT1, PGK1, LDHA) were downregulated, leading to reduced lactate production and enhanced oxygen consumption.
Knockdown of ITGAD reversed the effects on macrophage polarization and metabolic reprogramming.

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Implication

Randomized trial investigates how mechanical stress influences macrophage metabolism and polarization, suggesting new insights into pulmonary dysplasia.

Cite This Study

(40767) et al. (2026) studied this question.

synapsesocial.com/papers/6a2e44a3b1cc60ccdea8a28a https://doi.org/10.1016/j.cellsig.2026.112666

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Implication

Randomized trial investigates how mechanical stress influences macrophage metabolism and polarization, suggesting new insights into pulmonary dysplasia.

Mechanical stress attenuates the metabolic reprogramming and M1 polarization of macrophages by upregulating integrin subunit alpha D

Key Points

Discussion

Implication

Cite This Study

Mechanical stress attenuates the metabolic reprogramming and M1 polarization of macrophages by upregulating integrin subunit alpha D

Key Points

Discussion

Implication

Cite This Study

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